Gen Mthfr: Populyatsionnaya Genetika I Rol' Pri Koronarnom Ateroskleroze
| AUTHOR | Svarovskaya Mariya; Trifonova Ekaterina; Stepanov Vadim |
| PUBLISHER | LAP Lambert Academic Publishing (06/18/2012) |
| PRODUCT TYPE | Paperback (Paperback) |
Description
Arkhitektura neravnovesiya po stsepleniyu (LD) v genome cheloveka yavlyaetsya predmetom ozhivlennykh issledovaniy pri izuchenii demograficheskoy istorii populyatsiy i kartirovanii genov MFZ. Osnovoy raboty stalo vyyavlenie struktury gaplotipov i neravnovesiya po stsepleniyu v gene MTHFR u naseleniya Severnoy Evrazii i vyyavleniya osobennostey stroeniya dlya bol'nykh koronarnym aterosklerozom (KA). V rabote identifitsirovany informativnye markery (tagSNPs), opisyvayushchie strukturu gaplotipov v gene MTHFR; pokazan kharakter neravnovesiya po stsepleniyu v gene MTHFR u bol'nykh KA i provedyen analiz assotsiatsiy issledovannykh SNPs gena MTHFR s patogeneticheski znachimymi kolichestvennymi priznakami. Vpervye pokazano, chto struktura LD v gene MTHFR nosit populyatsionno-spetsifichnyy kharakter. Proizvedena otsenka vozrasta generatsii raznoobraziya po 12 SNP gena MTHFR. Vyyavlena rol' gaplotipov pri formirovanii KA v russkoy populyatsii. Naydeny assotsiatsii polimorfizmov rs7533315 i rs2066462 s KA. Polucheny dannye o vzaimosvyazi geneticheskoy variabel'nosti lokusa MTHFR u bol'nykh KA s patogeneticheski znachimymi pokazatelyami lipidnogo obmena, prodemonstrirovana vysokaya informativnost' gaplotipicheskogo podkhoda.
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Product Format
Product Details
ISBN-13:
9783659106057
ISBN-10:
3659106054
Binding:
Paperback or Softback (Trade Paperback (Us))
Content Language:
Russian
More Product Details
Page Count:
160
Carton Quantity:
50
Product Dimensions:
6.00 x 0.37 x 9.00 inches
Weight:
0.54 pound(s)
Country of Origin:
US
Subject Information
BISAC Categories
Science | Life Sciences - Genetics & Genomics
Descriptions, Reviews, Etc.
publisher marketing
Arkhitektura neravnovesiya po stsepleniyu (LD) v genome cheloveka yavlyaetsya predmetom ozhivlennykh issledovaniy pri izuchenii demograficheskoy istorii populyatsiy i kartirovanii genov MFZ. Osnovoy raboty stalo vyyavlenie struktury gaplotipov i neravnovesiya po stsepleniyu v gene MTHFR u naseleniya Severnoy Evrazii i vyyavleniya osobennostey stroeniya dlya bol'nykh koronarnym aterosklerozom (KA). V rabote identifitsirovany informativnye markery (tagSNPs), opisyvayushchie strukturu gaplotipov v gene MTHFR; pokazan kharakter neravnovesiya po stsepleniyu v gene MTHFR u bol'nykh KA i provedyen analiz assotsiatsiy issledovannykh SNPs gena MTHFR s patogeneticheski znachimymi kolichestvennymi priznakami. Vpervye pokazano, chto struktura LD v gene MTHFR nosit populyatsionno-spetsifichnyy kharakter. Proizvedena otsenka vozrasta generatsii raznoobraziya po 12 SNP gena MTHFR. Vyyavlena rol' gaplotipov pri formirovanii KA v russkoy populyatsii. Naydeny assotsiatsii polimorfizmov rs7533315 i rs2066462 s KA. Polucheny dannye o vzaimosvyazi geneticheskoy variabel'nosti lokusa MTHFR u bol'nykh KA s patogeneticheski znachimymi pokazatelyami lipidnogo obmena, prodemonstrirovana vysokaya informativnost' gaplotipicheskogo podkhoda.
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